anesthesia
Conditions
Interventions
Control group:Propofol
Sponsors
Minzu Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65-75 years, gender unlimited; 2. American anesthesiologist grade (ASA) I-II; 3. Patients requiring endotracheal intubation general anesthesia for elective surgery; 4. Body mass index (BMI) >=18 and =10 and =95% when breathing air;Systolic blood pressure (SBP) >=90mmHg and =60mmHg and =55 and <=100 beats/min; 6. Can understand the process and method of this study, and volunteer to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Those who have general anesthesia contraindications or have a history of anesthesia accidents in the past; 2. Known or suspected allergies or contraindications to propofol injection, cyclopofol injection excipients, benzodiazepines, opioids, muscle relaxants, etc.; 3. Patients with craniocerebral loss, intracranial hypertension, stroke, unstable angina, and myocardial infarction; 4. Respiratory insufficiency, obstructive lung disease, difficult airway or difficult tracheal intubation (modified Markov score is III or IV); 5. Uncontrolled diabetes or high blood pressure; 6. Severe liver dysfunction or severe renal insufficiency; 7. History of alcoholism or drug dependence; 8. Abuse or long-term use of narcotic, sedative, and analgesic drugs; 9. Those who have a history of mental illness; 10. Participated in any drug clinical trial within 1 month before screening; 11. The investigator believes that there are any other subjects who are not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of successful anesthesia induction;Length of disappearance of eyelash reflex;Changes in the Bispectral Index (BIS);Duration of operation;Study drug and alternative drug use;Satisfaction evaluation of anesthesia induction physicians;Incidence of postoperative delirium;Length of intubation;Length of stay in PACU; | — |
Countries
China
Contacts
Public ContactChen Jun
Minzu Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed