Lacunar infarction
Conditions
Sponsors
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Outpatients or inpatients aged 50-80 years and elderly residents of the community, education level >= 6 years; 2. There are objective lacunar infarcts detected by MRI, and the diameter of the lesion range from 215mm; 3. The score of Mini-Mental State Examination < 27, objective cognitive impairment; 4. No history or signs of stroke.
Exclusion criteria
Exclusion criteria: 1. Patients with severe heart, liver, and renal insufficiency (Note: Severe liver insufficiency refers to ALT value > 2 times the upper limit of normal or AST value > 2 times the upper limit of normal; severe renal insufficiency refers to creatinine value > 1.5 times normal upper limit); 2. There is coagulopathy, systemic bleeding, a history of coagulopathy or systemic bleeding, a history of thrombocytopenia or neutropenia; 3. Patients with other mental and nervous system diseases and malignant tumors; 4. Those who have participated in other drug trials within 3 months before being selected; 5. Those who have poor compliance or are dying and cannot complete the course of treatment; 6. Use other drugs to improve cognitive function such as ChEIs or other psychotropic drugs in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Full-Dimensional Cognitive Function Score;Mini-Mental State Examination;Auditory Verbal Learning Test;Complex Figure Test;Verbal Fluency Test;Digit Span Test;Stroop Colour-Word Test;Trails Test;Activities of Daily Living;Geriatric Depression Scale;Pittsburgh Sleep Quality Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Network Connections;Mean Diffusivity;Fractional Anisotropy; | — |
Countries
China
Contacts
Public ContactWei Dongfeng
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Outcome results
None listed