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Study on the syndrome characteristics of Phlegm-dampness Retention syndrome and Spleen and Kidney Yang Deficiency syndrome of dyslipidemia from the oxidative stress enhancement caused by inhibition of serine metabolic pathway

Study on the syndrome characteristics of Phlegm-dampness Retention syndrome and Spleen and Kidney Yang Deficiency syndrome of dyslipidemia from the oxidative stress enhancement caused by inhibition of serine metabolic pathway

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100046722
Enrollment
Unknown
Registered
2021-05-27
Start date
2021-05-27
Completion date
Unknown
Last updated
2022-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dyslipidemia

Interventions

spleen and kidney yang deficiency syndrome of dyslipidemia:None
phlegm turbidity suppression syndrome of dyslipidemia:None
Normal control group:None

Sponsors

Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria for dyslipidemia, spleen and kidney yang deficiency syndrome and phlegm turbidity suppression syndrome: (1) Aged 20-80 years, in line with the diagnostic criteria of spleen and kidney yang deficiency syndrome of dyslipidemia or phlegm turbidity suppression syndrome of dyslipidemia. (2) Patients who are willing to participate in the survey and have good compliance. (3) Patients whose blood lipid levels fluctuated in the past three months and did not take western medicine regularly. (4) Sign the informed consent form voluntarily. 2. Inclusion criteria for normal control group: (1) Aged 20-80 years. (2) Patients who are willing to participate in the survey and have good compliance. (3) The blood lipid test level is normal. (4) Sign the informed consent form voluntarily.

Exclusion criteria

Exclusion criteria: 1. Patients with secondary dyslipidemia (such as hypothyroidism, nephrotic syndrome, chronic renal insufficiency, primary diseases of the liver and hematopoietic system, adrenal corticosteroids and certain contraceptives, etc.). 2. Those who have cerebrovascular disease aphasia and cannot answer the questions clearly or cannot cooperate with the tongue. 3. Patients who are mentally abnormal or unable to answer questions normally. 4. Acute infectious diseases or the body is in a state of stress due to other reasons (such as acute myocardial infarction, acute cerebrovascular disease, etc.).

Design outcomes

Primary

MeasureTime frame
The scores of the scale of TCM syndromes;General data of patient;Blood routine;Blood biochemical;Blood coagulation function (including the D-dimer);Urine routine;Upstream factors related to serine metabolism pathway;Downstream factors associated with serine metabolic pathways;Oxidative stress related factors;Phosphoglycerate dehydrogenase;

Countries

China

Contacts

Public ContactYe Chao, Chen Jing

Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine

yechao@bucm.edu.cn+86 15910603713

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026