Atrial Fibrillation
Conditions
Interventions
Group 1:dual antiplatelet (aspirin+ticagrelor)
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 84 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years and = 2; 4. HAS-BLED score >= 3 or who refuse long-term anticoagulation therapy; 5. Successful occlusion of left atrial appendage with LACbes occluder; 6. Able to understand and give informed consent, and be able to accept follow-up (telephone and clinical follow-up).
Exclusion criteria
Exclusion criteria: 1. Mechanical prosthesis, evidence of thrombosis, complex atherosclerosis, or symptomatic carotid artery disease; 2. Contraindications of transesophageal echocardiography; 3. Platelet count < 60 x 10^9/L; 4. Left ventricular ejection fraction (LVEF) < 35%; 5. Severe renal failure, creatinine clearance rate < 30 ml/min/1.73m2 or severe liver disease defined as Child-Pugh score B or C; 6. Contraindications for any form of anticoagulation or antiplatelet therapy or allergy to the drug; 6. Patients who have a history of drug or alcohol abuse, or who are unable to quit drinking due to psychosocial reasons. 7. Patients with acute coronary syndrome treating with standard DAPT; 8. Injury or disease at significant risk of major bleeding; 9. A history of drug or alcohol abuse; 10. Pregnant or lactating women, or those who plan to become pregnant within one year; 11. Patients who have undergone catheter ablation for atrial fibrillation in the last three months; 12. The investigator judged that the patient had poor compliance and could not complete the study as required or the investigator judged that the patient was not suitable to participate in this study for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical thromboembolic events;device-related thrombosis;major bleeding;all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| nuisance bleeding;endothelialization; | — |
Countries
China
Contacts
Public ContactZhang Junfeng
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed