Diabetic Nephropathy
Conditions
Interventions
Control group:Live Combined Bifidobacterium and Lactobacillus Tablets
Sponsors
Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Type 1 or type 2 diabetic nephropathy; 2. Aged 18 to 70 years; 3. HbA1c<11%; 4. Diabetic gastrointestinal autonomic neuropathy (chronic diarrhea, constipation, or alternate diarrhea with constipation), recurrent Clostridium difficile infection, antibiotic-related diarrhea, refractory bowel disease (including intestinal infection, refractory Crohn's disease, refractory ulcerative colitis, intestinal fistula combined with infection, refractory constipation, etc.); 5. Responded poorly to conventional treatments for at least 3 months.
Exclusion criteria
Exclusion criteria: 1. Had a continuous antibiotic microecological preparations and other drugs that could influence intestinal flora for >3 days within 3 months prior to enrolment; 2. Had other causes of chronic kidney disease, such as various primary and secondary glomerulonephritis, renal tubular injury and renal vascular lesions, nephrotic syndrome, connective tissue disease, drug etc; 3. Serious heart disease, lung disease; 4. Difficult sedation of nerve, mental disorders, severe mental retardation, epileptic status; 5. Acute perforation of digestive tract was suspected; Shock coma, extreme weakness and inability to tolerate; 6. Acute stage of upper digestive tract corrosive inflammation, massive ascites, severe abdominal distension, severe spinal deformity, aortic aneurysm, acute peritonitis or extensive adhesion in the abdominal cavity; 7. Patients who cannot cooperate and are not suitable for general anesthesia, severe hemorrhagic diseases, abnormal coagulation function, poor immune status, and long-term use of immunosuppressant 8. Patients with severe intestinal ulcer, gastrointestinal malformation, postoperative adhesion, and organic obstruction; 9. Had a physical disability or self-care disability or were unable to recall clearly and answer questions due to any other reasons; lacked the time to take part in this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour urinary protein quantity;Urine trace albumin;Glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Venous blood sugar;Blood urea nitrogen;Serum creatinine;Urine trace albumin/creatinine; | — |
Countries
China
Contacts
Public ContactXu Yong
Affiliated Hospital of Southwest Medical University
Outcome results
None listed