postoperative cognitive dysfunction
Conditions
Interventions
experimental group 1:rimimazolam tosilate 0.1mg/kg
experimental group 2:rimimazolam tosilate 0.2mg/kg
experimental group 3:rimimazolam tosilate 0.3mg/kg
control group:???? 0.2mg
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years, gender unlimited. 2 ASA grade was I – III. 3. 18 kg / m2 <= BMI <= 28 kg / m2. 4. General anesthesia patients receiving unilateral knee surgery. 5. Patients voluntarily participated in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic or taboo to benzodiazepines, opioids, propofol, flumazene, naloxone and their drug components. 2. Acute heart failure. Unstable angina. Myocardial infarction occurred within 6 months before screening. Resting ECG heart rate = 160 mmHg or SBP <= 90 mmHg in the screening period ). 5. Patients with obvious abnormal liver and kidney functions. 6. Patients with craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, cerebrovascular accident history and central nervous system diseases. 7. Patients with mental system diseases and long-term history of taking psychotropic drugs and cognitive dysfunction. 8. Patients who participated in any clinical trial within three months before selection. 9. Other conditions that are not suitable for inclusion are determined by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction; | — |
Countries
China
Contacts
Public ContactGong Taowu
The Affiliated Hospital of Zunyi Medical University
Outcome results
None listed