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The immune efficiency and safety of extended use of platinum based doublet chemotherapy plus 72h CIV endostatin in patients with advanced nonsmall cell lung cancer

The immune efficiency and safety of extended use of platinum based doublet chemotherapy plus 72h CIV endostatin in patients with advanced nonsmall cell lung cancer

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046608
Enrollment
Unknown
Registered
2021-05-22
Start date
2021-05-17
Completion date
Unknown
Last updated
2022-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

experimental group:endostatin
control group:No

Sponsors

The Affiliated Hospital of Jiangnan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients with advanced NSCLC confirmed by cytology or histology (patients who do not receive a separate sputum cytology diagnosis); 2. According to the 8th edition of the lung cancer staging system (TNM staging) TNM new staging is judged to be stage IIIB or stage IV 3. It must have at least one evaluable lesion (at least 10mm in the longest diameter on enhanced CT) judged according to the RRECIST version 1.1 standard; 4. Male or female, aged 18 to 75 years; 5. ECOG PS 0-1; 6. The expected survival period is >=3 months; 7. White blood cells > 3.0x10^9/L, platelets > 75x10^9/L, hemoglobin (HB) >= 90g/L; 8. Liver and kidney function are normal; 9. The electrocardiogram is basically normal, and there is no unhealed wound on the body 28 days before the operation; 10. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Combined with mental illness; 2. Women during pregnancy or breastfeeding 3. Those with bleeding tendency; 4. The investigator believes that the patient should not participate in other situations in this trial.

Design outcomes

Primary

MeasureTime frame
Progression-free survival;Overall efficiency;Safety;

Countries

China

Contacts

Public ContactChen Xiaoping

The Affiliated Hospital of Jiangnan University

1165079792@QQ.COM+86 18861530273

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026