Polycystic ovary syndrome
Conditions
Interventions
PCOS patients with or without insulin resistance group, insulin resistant patients, normal control group:Nil
Sponsors
The Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis of PCOS is based on the diagnostic criteria of the European Society of Human Reproduction and Embryology in Rotterdam and the American Society of Reproductive Medicine (ESHRE/ASRM) in 2003, which stipulate that the diagnosis requires any 2 of the following 3 items: (1) Rare ovulation and/or anovulation; (2) Clinical manifestations and/or excessive androgen; (3) Ultrasound detection of ovarian polycystic changes, that is, >=12 follicles with a diameter of 2-9mm in one or two ovaries, or ovarian volume >=10 ml; 2. All patients were evaluated with positive glucose hyperinsulinemic clamp (EHC) technology; M value (glucose metabolism rate) less than 6.286 mg/kg/min indicates IR, and M value greater than or equal to 6.286 mg/kg/min indicates non-IR.
Exclusion criteria
Exclusion criteria: 1. Aged over 40 years; 2. Body mass index (BMI) is greater than 35 kg/m2; 3. There are other diseases that cause infertility; 4. There are obvious signs or symptoms of liver and kidney disease, alanine aminotransferase is higher than 2 times the normal value, serum creatinine is higher than normal, severe gallstones, triglycerides higher than 5mmol/L, heart failure, thyroid disease, Or have a history of diabetes; 5. Use of drugs that affect glucose and lipid metabolism within the last 3 months; 6. A history of mental disorders or alcohol or drug abuse in the past 3 years; 7. Have a history of allergies or contraindications to the study drug (Exenatide (EX) injection); 8. Positive urine HCG or reluctance to take strict contraceptive measures during the research process; 9. Participate in other drug trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CYP17A1; | — |
Countries
China
Contacts
Public ContactLiao Xin
The Affiliated Hospital of Zunyi Medical University
Outcome results
None listed