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A cross-sectional and cohort study of the effect of APOE, SPP1 and VDR polymorphisms on the occurrence and progression of diabetic cardiomyopathy in type 2 diabetic population

A cross-sectional and cohort study of the effect of APOE, SPP1 and VDR polymorphisms on the occurrence and progression of diabetic cardiomyopathy in type 2 diabetic population

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100046597
Enrollment
Unknown
Registered
2021-05-22
Start date
2021-06-01
Completion date
Unknown
Last updated
2022-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic cardiomyopathy

Interventions

case series:No

Sponsors

The University of Hong Kong- Shenzhen Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. T2DM patients who meet the 1997 WHO Diabetes Diagnostic Criteria; 2. Age over 18 years old.

Exclusion criteria

Exclusion criteria: 1. Patients with a clear history of cardiovascular disease, including coronary atherosclerotic heart disease, myocardial infarction, heart stent implantation, pacemaker implantation, valvular heart disease, congenital heart disease, viral infection or family Sexual or invasive cardiomyopathy; 2. Patients with malignant tumors receiving radiotherapy and chemotherapy; 3. Severe liver and kidney function damage; 4. People who are pregnant and who refuse to participate.

Design outcomes

Primary

MeasureTime frame
gene polymorphisms of ApoE, SPP1 and VDR;Left ventricular structure, systolic and diastolic function;Changes of left ventricular strain capacity in 2 years;—

Countries

China

Contacts

Public ContactYao Qiheng

The University of Hong Kong - Shenzhen hospital

khkyiu@hku.hk+86 18664966886

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026