Coronary arteries are vascular diseases
Conditions
Interventions
Sponsors
Zhongshan Hoapital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet one of the following four items: (1) Spontaneous or exertional chest pain with ST-segment depression of ECG, the application of nitrate ester drugs is ineffective (the most common); (2) Myocardial stress perfusion realizes reversible perfusion defect; (3) Cardiac MRI and ultrasound suggest evidence of load-related coronary blood flow abnormalities; (4) Metabolic evidence of transient myocardial ischemia (confirmed by cardiac MRI or invasive examination); 2. Coronary angiography or coronary CTA showed mild stenosis of the main branch vessels (<50%); or PCI was performed within 3 years, but the main branch vessels were mildly stented (<50%); 3. Patients between the ages of 18-65 (including 18 and 65 years old) are not limited to men and women; 4. The patient voluntarily followed up and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to Kuanxiong aerosol or its components (asarum oil, sandalwood oil, galangal oil, long pepper oil, borneol) or any component of the drug; 2. Persistent severe angina pectoris (CCS grade IV); 3. Severe ST-segment depression during exercise test level 1 in the past month; 4. Patients with heart failure with left ventricular ejection fraction (LVEF) 400pg/ml; 5. Prepare to perform CABG or PCI during the test; 6. The four criteria of blood fat, blood sugar, blood pressure and uric acid: (1) With or without drug control, blood lipid exceeds 1.5 times the upper limit of the normal reference value; (2) Diabetic patients with poor blood glucose control (patients with previous diagnosis of diabetes had HbA1c >6.5% before participating in this study;Had not been diagnosed with diabetes before, and it was found that diabetic patients had HbA1c >7.5% during screening); (3) uncontrolled severe hypertension, systolic blood pressure > 180mmHg and/or diastolic blood pressure > 110mmHg; (4) Uric acid exceeds 1.5 times the upper limit of the normal reference value; 7. Renal dysfunction (CR > 1.5 times the upper limit of the normal reference value) 8. Patients with severe liver disease or liver dysfunction (ALT, AST or TBIL>1.5 times the upper limit of the normal reference value); 9. Any other serious disease or condition such as malignancy; 10. Severe arrhythmias (such as rapid atrial fibrillation, ventricular tachycardia, high atrioventricular block, etc.); 11. Participated in another clinical study or had been randomized to the study within 30 days prior to enrollment; 12. A woman who is pregnant or preparing to become pregnant; 13. Patients determined by the investigator to be unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of Seattle Angina Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| ECG changes (ST-T segment changes);Changes of cardiac function indexes (LVEF, LVEDD);Changs of BNP;Changes of Troponin T;Changes of blood lipid;C-reactive protein changes;Changes in the Quality of Life Scale (SF-12);Changes in the Depression Screening Scale(PHQ-9);Changes in the Panic Disorder Severity Scale;Changse in the Anxiety Screening Scale;Changes in the Life event scale; | — |
Countries
China
Contacts
Public ContactPeng Juan
Zhongshan Hospital, Fudan University
Outcome results
None listed