Cerebrovascular disease
Conditions
Interventions
test group:intravenous infusion of tirofiban
control group:Standard antiplatelet therapy
Sponsors
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years; 2. The onset time is 6-72h; 3. Symptoms fluctuate within 24 hours of onset; 4. Admission NIHSS score 4-10 points; 5. Brain MRI showed that the lesion on DWI was less than 1/3 of the area dominated by MCA/PCA or there were multiple spots, small patches or irregular high signals. MRA ruled out large vessel occlusion, and brain CT ruled out intracranial hemorrhage; 6. ECG and ECG monitoring to rule out heart diseases such as atrial fibrillation; 7. Having two or more of high-risk factors such as hypertension, hyperlipidemia, and hyperglycemia; 8. The family members sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with thrombolysis and thrombectomy; 2. Intracranial stenosis and occlusion of large blood vessels; 3. Past history of intracranial hemorrhage; 4. Platelet count 185mmHg or diastolic blood pressure>110mmHg; 7. Patients with severe liver and kidney insufficiency or severe diabetes; 8. Patients with incomplete information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic intracranial hemorrhage;NIHSS score;mRS score after three months treatment;Blood cell test;Blood coagulation index;Changes of infarct size in MRI;Non-symptomatic hemorrhage; | — |
Countries
China
Contacts
Public ContactLiang Zhigang
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University
Outcome results
None listed