Knee osteodystrophy
Conditions
Interventions
R group:0.375% ropivacaine 20ML
R+D 0.5 group:0.375% ropivacaine 20ml + 0.5 g/kg Dexmedetomidine
R+D1.0 group:0.375% ropivacaine 20ml + 1.0 g/kg Dexmedetomidine
R+D1.5 group:0.375% ropivacaine 20ml + 1.5 g/kg dexmedetomidine
Sponsors
The First Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40 to 79 years; 2. American Association of Anesthesiologists (ASA) classification I ~ III; 3. Body Weight 45-80kg, BMI & Lt; 35Kg/m2; 4. With unilateral and severe osteoarthritis/osteodystrophy; 5. General anesthesia is the plan.
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to Dexmedetomidine, Ropivacaine or other amides; 2. SINUS Bradycardia (P & Lt; 50 Beats/min) or Atrioventricular Block; 3. Previous neurological disease, Coagulopathy, or current use of anticoagulants; 4. Chronic heavy use of sedatives, analgesics or severe alcoholism; 5. Severe Heart, lung, liver, kidney and other important organ diseases; 6. Past Surgical History of the knee; 7. Broken or localized infection at the puncture site of the adductor; 8. Participation in other clinical studies; 9. Refusal to participate or withdrawal request; 10. Any other reason for not cooperating with the study, example: mental illness, language comprehension disorder, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue pain scale;Ramasy sedation score;he number of cases of Tramadol in each group, and the time of the first tramadol administration; | — |
Secondary
| Measure | Time frame |
|---|---|
| The amount of anesthetic used during the operation;The number of patients with hypotension in each group;The number of Bradycardia occurred in each group;The number of patients in each group who required atropine treatment;Spontaneous breathing recovery time;Patient extubation time; | — |
Countries
China
Contacts
Public ContactYuelan Wang
Qianfoshan Hospital
Outcome results
None listed