Lung Cancer
Conditions
Interventions
S-Ketamine Group:S-Ketamine
Control Group:saline
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ASA classification I~III; 2. Aged 18 to 65 years; 3. Patients who plan to undergo thoracoscopic lobectomy.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to the use of esketamine; 2. History of psychosis; 3. Cognitive dysfunction; 4. History of lung surgery; 5. Those who use hormone therapy during the operation; 6. Alcoholism or frequent use of sedative and analgesic drugs; 7. Severe liver, kidney, cardiovascular and other systemic diseases; 8. History of stroke, history of head trauma, history of intracranial mass or hemorrhage; 9. Unable to communicate; 10. Participate in other drug trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality score(QOR-40); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications;Hospital Anxiety and Depression Scale;Visual analog scale score;Pain assessment after chest and abdomen surgery (Prince-Henry score);Interleukin-6, Interleukin-8, Interleukin-10, Tumor Necrosis Factor-a; | — |
Countries
China
Contacts
Public ContactCheng Xiang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed