Dura defect
Conditions
Interventions
Experimental group vs control group:dural patch
Sponsors
General Hospital of Tianjin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years; 2. Patients with dural defect caused by various reasons (such as brain injury, brain tumor, cerebrovascular disease, congenital nervous system disease, spine disease, etc.) and who need surgical repair; 3. The surgical incision grade is Grade I; 4. The estimated survival period is greater than 6 months; 5. The patient agrees to participate in the clinical trial, signs an informed consent form, and can complete the follow-up of the clinical trial.
Exclusion criteria
Exclusion criteria: 1. Patients with intracranial metal implants that will affect imaging evaluation; 2. The patient has serious organic diseases (heart, liver, kidney, circulatory system, etc.); 3. Patients with unstable vital signs; 4. Patients with coma and/or lethargy (Glass coma score <8); 5. Patients who are allergic to known substances or drugs during the test; 6. Patients with local craniocerebral infection and hydrocephalus; 7. Acute malignant encephalocele during the operation causes difficulty in closing the skull; 8. Patients who need radiotherapy and/or chemotherapy within 12 weeks before surgery and (or) 10 weeks after surgery; 9. Uncontrolled diabetes, sepsis, systemic connective tissue disease (rheumatism, systemic lupus erythematosus, etc.) or suffering from autoimmune diseases; 10. Patients who have participated in other clinical trials within 2 months; 11. Women during pregnancy or lactation; 12. Other researchers believe that it is not suitable to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of prevention of postoperative cerebrospinal fluid leakage; | — |
Countries
China
Contacts
Public ContactYue Shuyuan
General Hospital of Tianjin Medical University
Outcome results
None listed