Ocular fundus disease
Conditions
Interventions
control group (Fundus disease patient):Anti-VEGF therapy
experimental group (fundus disease patient):Anti-VEGF therapy+DEX
control group (senile cataract patient):Nil
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Test group (fundus disease patient group): Inclusion criteria: 1.CNV patients (age >=18 years old), DME and RVO patients (age >=40 years old) who agreed to participate in this study; 2.Slit lamp microscope, fluorescein fundus angiography (FFA), indocyanine green angiography (ICGA), optical coherence tomography (OCT) and/or optical coherence tomography Scanning angiography (optical coherence tomography angiography, OCTA) examination, diagnosed as CNV, DME, RVO and other ocular fundus diseases; 3.The eye position is normal and the central fixation point is good; 4.No history of eye trauma or other eye diseases; 5.Non-contact tonometer measures intraocular pressure <=21mmHg; 6.During the treatment of fundus disease, follow-up can be maintained. Control group (senile cataract patient group): Inclusion criteria: 1.Agree to participate in this research; 2.The diagnosis of senile cataract is in line with the indications for cataract surgery; 3.No history of eye trauma or any other eye diseases (such as diabetic retinopathy, age-related macular degeneration, choroidal neovascularization, uveitis, glaucoma, retinal detachment, etc.); 4.No history of serious systemic diseases such as nervous system and immune system; Non-contact tonometer measures intraocular pressure <=21mmHg.
Exclusion criteria
Exclusion criteria: Test group (fundus disease patient group): Exclusion criteria: 1.Have received treatment for ME within the past year (such as anti-VEGF drugs, triamcinolone acetonide, compound anisodine, dexamethasone vitreous implants, retinal laser photocoagulation, etc.); 2.During FFA, ICGA, OCT, OCTA examinations, the ophthalmological examination cannot be completed due to incorrect eye position and poor fixation; 3.Due to intraocular hemorrhage, severe senile cataract and other reasons, the refractive interstitium is unclear, and the results of eye examination cannot be analyzed; 4.Have a history of eye trauma, or have received other eye surgery except cataract surgery and myopia laser surgery; 5.Incomplete medical records, other eye diseases or serious systemic diseases cannot be ruled out. Control group (senile cataract patient group): Exclusion criteria: 1.During OCT and OCTA examinations, they cannot cooperate well due to incorrect eye position or poor fixation; 2.The medical records are incomplete, and other eye diseases or serious systemic diseases cannot be ruled out.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aqueous humor cytokine content;Area of choroidal neovascularization;Retinal thickness;Choroidal thickness;Visual acuity; | — |
Countries
China
Contacts
Public ContactSun Xufang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed