Multiple injuries
Conditions
Interventions
Group TI:I.V. Nalbuphine Hydrochloride 100ug/kg/h
Group T2:I.V. Remifentanil Hydrochloride 0.5ug/kg/h
Group T3:I.V. Nalbuphine Hydrochloride 100ug/kg/h+Remifentanil Hydrochloride 0.5ug/kg/h
Sponsors
The Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of multiple injuries, two doctors who have been engaged in emergency and severe illness for more than 2 years jointly evaluate patients who need continuous analgesia, and the continuous analgesia time is >= 48h; 2. Aged 18-65 years old; 3. Survival time > 2 weeks.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to opioids; 2. Patients with bradycardia (heart rate <= 50 beats /min), ? degree ATrioventricular block, systolic blood pressure <90 mmHg; 3. Pregnant or lactating women; 4. Patients with a history of mental illness; 5. Patients with severe liver and kidney insufficiency, severe brain stem failure, and severe cardiopulmonary dysfunction; 6. Endocrine disorders, acute and chronic neuromuscular diseases, and diseases of the blood system; 7. Patients with malignant tumor and pain, history of long-term analgesic use, history of chronic pain; 8. Patients considered unsuitable for clinical trials by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of morphine required to maintain the ideal analgesic effect (COPT 0-1 points) for each group of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;Duration of ICU stay;Duration of hospital;Inflammatory mediator level; | — |
Countries
China
Contacts
Public ContactGu Zhengtao
The Third Affiliated Hospital of Southern Medical University
Outcome results
None listed