Wrinkles
Conditions
Interventions
Group A:Non-ablative fractional laser
Group B:Soluble hyaluronic acid microneedle
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients of 18-65 years old; 2. Infraorbital wrinkles assessment standard score 3 points and above; 3. Meet the static crow's feet grading standard 3 and above; 4. Voluntarily sign an informed consent to participate in the clinical trial.
Exclusion criteria
Exclusion criteria: 1. Those who are known to be allergic to test drugs or related drugs; 2. Pregnant or lactating women; 3. Received wrinkle treatment (laser, radio frequency, fruit acid, photon, hyaluronic acid filling, etc.) within 6 months before enrollment; 4. Those who have other diseases (infection, dermatitis, sunburn, scars, etc.) that may affect the evaluation of the efficacy of the facial treatment area and nearby areas; 5. Received anti-inflammatory, glucocorticoid or tretinoin treatment within 1 month before enrollment; 6. Participate in any drug clinical trial (as a subject) within 1 month before participating in this trial; 7. Combined with serious diseases, including severe heart disease, cerebrovascular disease, uncontrolled diabetes, uncontrolled high blood pressure, etc.; 8. Those with scar constitution; 9. Subjects with severe physical or mental illness that the investigator believes may affect treatment, evaluation, or poor compliance with the research protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VISIA photos of wrinkles; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects; | — |
Countries
China
Contacts
Public ContactWang Xiuli
Shanghai Skin Disease Hospital
Outcome results
None listed