Emergence time from anesthesia
Conditions
Interventions
control group:Intraoperative administration of normal saline
experimental group:Intraoperative administration of s-ketamine
Sponsors
The First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 60 years; 2. ASA level: I-II; 3. The Han nationality; 3. Patients undergoing laparoscopic surgery under general anesthesia; 4. Signing the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1. Having a history of neurological or psychiatric disease; 2. Cognitive impairment; 3. Taking sedatives or anti-depression medicine within 1 week; 4. Addicted to alcohol or psychiatric medicine(drinking more than 40 degrees of alcohol more than 100 ml a day at least 3 months before the onset of the disease; can not get rid of the desire to use alcohol or drugs, and the will to take the drugs increases significantly); 5. Having operations within one month; 6. Communication disorder (existing language problem, being blind and deaf); 7. The expected operation time was less than 1 hour and more than 3 hours; 8. Have participated in other clinical trials within 3 months; 9. The same patient could not be included once again, regardless of whether the cause of the operation is related to the first disease or not; 10. The BMI was less than 18 or more than 28 kg/m2; 11. Contraindications of ketamine (poorly controlled or untreated hypertension (resting blood pressure greater than 180/100mmHg), diagnosed intracranial hypertension and pulmonary hypertension on admission, untreated or undertreated hyperthyroidism, required uterine muscle relaxation, such as uterine tearing / rupturing, umbilical cord prolapsing, etc, patients with unstable angina pectoris or myocardial infarction or congestive heart failure in the past six months, alcoholism, substantial hepatic impairment, sensitivity to ketamine).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence time of sevoflurane anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change of EEG Index and the intensity and maximum Frequency of gamma Oscillation in EEG;Changes of beta/gamma, alpha, low frequency wave intensity and frequency after intraoperative administration of tested drugs;Delirium score 1 day after operation;Evaluation of cognitive function 1 day after operation;Dysphoria score during recovery period;The proportion and duration of burst suppression ratio during operation; | — |
Countries
China
Contacts
Public ContactYang Qianzi
The First Affiliated Hospital, the Air Force Medical University
Outcome results
None listed