Acute Hypoxemic Respiratory Failure
Conditions
Interventions
HFNC success group vs.HFNC failure group:Nil
Sponsors
Zhongda Hospital, School of Medicine, Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years and 25 times/min; (2)Patients with oxygen flow >= 10L/min, P/F<= 300mmHg and PaCO2 <= 45mmHg; 3. Signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe asthma or chronic respiratory failure (including chronic obstructive pulmonary disease or other underlying chronic respiratory disease); 2. Hemodynamic instability, SBP15µg/kg/min, noradrenaline >15 ug/min); 3. Cardiogenic pulmonary edema; 4. Severe granulocytopenia (< 500/mm3) and hematologic malignancies; 5. Glasgow Coma Scale score <= 12; 6. Due to nosebleed, recent nasal surgery or other reasons, the high-flow oxygen therapy catheter cannot be used through the nose; 7. Noninvasive ventilation contraindications: facial, neck and oropharyngeal trauma, burns, deformity or recent surgery;Upper respiratory tract obstruction;Diseases with high risk of aspiration, such as vomiting and gastrointestinal bleeding;Recent major esophagus and upper abdominal surgery. 8. Immediate endotracheal intubation is required (life-threatening hypoxemia PaO2/FiO2<50mmHg, cardiac or respiratory arrest, etc.), refused endotracheal intubation, and refused to participate in the study; 9. Patients who will be selectively intubated for diagnosis or treatment (fiberoptic bronchoscopy, surgery, etc.); 10. Patients who are currently participating in other studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubation rate in ICU; | — |
Countries
China
Contacts
Public ContactChen Dongyu
Zhongda Hospital, School of Medicine, Southeast University
Outcome results
None listed