recurrent spontaneous abortion, GDM
Conditions
Interventions
Use glucocorticoid vs not used glucocorticoid:Nil
Sponsors
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Women of childbearing age aged 25-40 years; 2. Spontaneous abortion >=2 times; 3. Did not take glucocorticoid in the past 3 months.
Exclusion criteria
Exclusion criteria: 1. Diabetes was diagnosed before pregnancy. 2. Before pregnancy, it has been diagnosed as PCOS and other endocrine diseases that may affect its own glucose metabolism. 3. Glucocorticoid was used in the past 3 months. 4. Known HIV positive and / or screening visit, HBsAg or HCV antibody positive. 5. Liver disease was defined as ALT or AST > 3 ULN. 6. The malignant tumors occurred in the past 5 years (except for the skin squamous basal cell carcinoma which has been resected and considered cured). Subjects who developed malignancies five years ago should provide evidence of remission or cure. Subjects with a history of cervical cancer who had undergone conization or cure in the past 3 years were eligible. 7. Patients with a history of chronic infection such as Mycoplasma, chlamydia, Cryptococcus and invasive fungal infection should be discussed with the main researchers. 8. History of active tuberculosis (TB) or evidence of previous TB infection. Subjects with a history of potential TB infection should also be excluded, unless there is a documented evidence that they have completed appropriate anti TB treatment in accordance with CDC guidelines or local regulations before screening. In addition, subjects were strictly forbidden to have any clinical symptoms / signs of active TB.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose level; | — |
Secondary
| Measure | Time frame |
|---|---|
| C peptide;Glycosylated Hemoglobin;Obstetric complications;Fetal outcomes; | — |
Countries
China
Contacts
Public ContactAimin Zhao
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed