Helicobacter pylori infection
Conditions
Interventions
control group:esomeprazole 20mg / time, 2 times / day + Colloidal Bismuth Pectin for Suspension 150mg / time, 3 times / day + amoxicillin 1000mg / time, 2 times / day + clarithromycin 500mg / time, 2
Experimental group: esmoprazole 20mg / time, 4 times / day + amoxicillin 1000mg / time, 3 times / day, the course of treatment was 14 days.
Sponsors
Haikou People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18 to 65 years; 2. HP infection was diagnosed by C13 / C14 urea breath test or immunohistochemical staining of biopsy samples; 3. There were indications for HP eradication, but no countervailing factors; 4. No HP eradication treatment was received in the past; 5. No antibiotics, bismuth and antibacterial active Chinese medicine were taken 4 weeks before treatment, and no PPI, H2 receptor antagonist and other drugs affecting HP activity were taken 2 weeks before treatment; 6. Patients were informed and agreed to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Patients with severe heart, liver, lung and kidney dysfunction and low immunity; 2. There were contraindications to penicillin or related drugs; 3. Those with mental illness and communication disorder; 4. Pregnancy and lactation; 5. The patients with organic diseases such as gastrointestinal tumor and gastrointestinal hemorrhage; 6. Those who are participating in other clinical experiments; 7. The researchers think that it is not suitable to be enrolled.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliance;Adverse reactions;Treatment cost; | — |
Countries
China
Contacts
Public ContactHuang Xiaoxi
Haikou People's Hospital
Outcome results
None listed