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Effects of ultrasound-guided nerve block combined with general anesthesia on hypercoagulability and the levels of serum MCP-1 and NLRP3 in patients undergoing arthroscopic knee surgery

Effects of ultrasound-guided nerve block combined with general anesthesia on hypercoagulability and the levels of serum MCP-1 and NLRP3 in patients undergoing arthroscopic knee surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046430
Enrollment
Unknown
Registered
2021-05-15
Start date
2021-06-15
Completion date
Unknown
Last updated
2022-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee arthroscopy

Interventions

Experimental group:Ultrasound guided nerve block combined with general anesthesia
Control group:General anesthesia

Sponsors

Wuxi 9th People's Hospital Affiliated to Soochow University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. All patients underwent knee arthroscopic surgery; 2. Osteotomy: there is knee varus/valgus deformity; 3. There are loose knee joints, often interlocking and meniscus interlocking; 4. All patients signed an informed consent form, and performed regular rehabilitation exercises in accordance with the rehabilitation plan after the operation; 5. The patient has normal communication.

Exclusion criteria

Exclusion criteria: 1. Systemic or local infectious diseases (such as fever caused by infection) appear; 2. Combined with severe hypertension, heart disease, diabetes or other serious diseases; 3. Before the operation, the skin near the knee joint was bitten by mosquitoes, causing skin boils and swelling; 4. Patients with mental disorders; 5. Patients who failed to return visit after operation; 6. Patients who do not cooperate with this research program.

Design outcomes

Primary

MeasureTime frame
Anesthesia onset time, recovery time;Analgesia Index;Hypercoagulable state;MCP-1, NLRP3 levels;Adverse reactions;

Countries

China

Contacts

Public ContactJi Jiawei

Wuxi 9th People's Hospital Affiliated to Soochow University

wxjyjjw1108@126.com+86 18851572787

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026