epilepsy
Conditions
Interventions
Experimental group:pulvinar stimulation on
Control group:pulvinar stimulation off
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 14 to 65 years; 2. Diagnosed as refractory epilepsy.(resistant to AED medication for at least 2 years); and considering as the posterior cortex epilepsy after comprehensive presurgical evaluation. 3. With difficulty in the removal of epileptic tissue, or refusal of resection surgery; 4. At least 4 seizures per month; 5. Agree to participate in this study and signed on the informed consent; 6. Comply with the protocol of this study and agree on the follow-up examination as request.
Exclusion criteria
Exclusion criteria: 1. Suffer from brain tumors or other degenerative diseases of the central nervous system; 2. Existing mental illness; 3. There are structural changes in the thalamus occipital; 4. Severe cognitive dysfunction, IQ<55; 5. Comprehensive or special types of hereditary epilepsy; 6. Pregnant women may have a high risk of bleeding; 7. Other serious physical diseases or severe abnormal liver and kidney function in laboratory tests; 8. Patients who cannot complete the electrical stimulation test due to objective factors; 9. Abnormal laboratory examinations during the screening period, or other abnormal laboratory examinations considered to be clinically important.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency and severity of seizures; | — |
Secondary
| Measure | Time frame |
|---|---|
| The patient's quality of life (QOLIE-31 scale);The score of anxiety scale (GAD-7) and depression scale (NDDI-E); | — |
Countries
China
Contacts
Public ContactRen Liankun
Xuanwu Hospital, Capital Medical University
Outcome results
None listed