multiple system atrophy
Conditions
Interventions
Experimental group:Drug (tolterodine) combined with electrical stimulation
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Possible shrinkage of multiple systems. 2. Has symptoms of frequent urination and urgency without treatment. 3. Accepted urology-neurology diagnosis and treatment, followed up for 2 weeks. 4. Bladder ultrasound: residual urine = 30 years and <= 75 years. 6. The overall disability level is 1, 2, and 3. 7. Urine routine bacteria (-). 8. Male urodynamic force: 20cmH2O <= detrusor contraction force <= 60cmH2O, maximum free urine flow rate <= 10 mL/s; female urodynamic force: detrusor contraction force exists, and maximum free urine flow rate <= 10 mL/s.
Exclusion criteria
Exclusion criteria: 1. Cannot urinate at all. 2. Language: severely affected, often (more than half of the time) asked to repeat the statement; or in most cases unable to understand. 3. Swallowing: obviously abnormal, frequent food inhalation; or nasal feeding or gastrostomy. 4. Walking: severe abnormality, often needs assistance and/or assistive tools from others; or unable to walk even with assistance. 5. Lung infection (chest X-ray or CT). 6. Stress urinary incontinence. 7. There are sequelae of cerebral infarction. 8. History of previous urethral surgery. 9. Impaired renal function. 10. Male patients with benign prostatic hyperplasia. 11. Drug treatment contraindications: (1) Patients with urinary retention, gastric stagnation, and uncontrolled narrow-angle glaucoma; (2) Patients who have been confirmed to have allergic reactions to this product; (3) Patients with myasthenia gravis, patients with severe ulcerative colitis, and patients with toxic megacolon. 12. Electrical stimulation contraindications: use of a pacemaker, pregnancy, undiagnosed pain symptoms, undiagnosed skin, vaginal and anal diseases, skin under anesthesia or desensitization, urinary tract infection or vaginal infection is being treated recently, the irritated part is suffering from disease, the damaged tissue of the irritated part is being cured, diabetes or high blood pressure, abnormal cervical smear examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective urination score; | — |
Secondary
| Measure | Time frame |
|---|---|
| International prostatesymptom score;Overactive bladder score; | — |
Countries
China
Contacts
Public ContactCao Gan
Xuanwu Hospital, Capital Medical University
Outcome results
None listed