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Clinical study of intestinal microflora and its metabolites in autistic children based on MALDI-TOF and HPLC-MS

Clinical study of intestinal microflora and its metabolites in autistic children based on MALDI-TOF and HPLC-MS

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100046377
Enrollment
Unknown
Registered
2021-05-15
Start date
2021-07-01
Completion date
Unknown
Last updated
2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Disorders

Interventions

Autism group:Symptomatic treatment

Sponsors

Shenyang Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 16 Years

Inclusion criteria

Inclusion criteria: 1. Autism group: The children were diagnosed with ASD, which met the criteria of the fifth edition (DMS-5) of the Diagnostic and Statistical Manual of Mental Disorders. An experienced developmental and behavioral pediatrician used the Child Autism Rating Scale (CARS) to further confirm this diagnosis; 2. Control group: recruit healthy and normal children (not related to autistic individuals) whose gender and age match the children with ASD from the children undergoing physical examination in the Department of Pediatrics of Shenyang Children's Hospital. The recruiter did not receive antibiotics, antifungal therapy, probiotic therapy, or any other medications that might affect the gut microbiota within 3 months before being included in the study. At the same time, if children with autism have siblings, they will be included in the control group after obtaining parental consent and signing an informed consent form.

Exclusion criteria

Exclusion criteria: Children with ASD have a history of Rett syndrome, cerebral palsy, other congenital diseases, and acute and chronic affective diseases in the past 3 months.

Design outcomes

Primary

MeasureTime frame
Height;microbiota;Metabolites;weight;BMI;

Countries

China

Contacts

Public ContactLi Na

Shenyang Children's Hospital

706502446@qq.com+86 13709851045

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026