multiple myeloma
Conditions
Interventions
CAR T cell first-line consolidation group:CAR T-cell
Sponsors
The Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed multiple myeloma patients; 2. Aged more than 18 years and less than 70 years; 3. Suitable for transplantation or uncomfortable transplantation; 4. Estimated survival time> 12 weeks; 5. The ECOG PS score is less than 2 points; 6. The patient has no serious liver, cardiovascular and cerebrovascular diseases; 7. The patient has no infectious diseases such as HIV, active tuberculosis, and syphilis; 8. The patient does not have other malignant tumors at the same time; 9. If the patient has renal insufficiency, GFR>30mL/min is required; 10. Able to understand and voluntarily sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Women who are pregnant or breastfeeding, or women who have a pregnancy plan within six months; 2. The feasibility assessment and screening prove that the transfection of targeted lymphocytes is <10% or the expansion is insufficient under CD3/CD28 co-stimulation (< 5 times); 3. Abnormal vital signs, and those who cannot cooperate with the examination; 4. People with mental or mental illnesses who cannot cooperate with treatment and efficacy evaluation; 5. Subjects requiring anti-infection treatment for systemic infections or severe local infections; 6. Subjects with severe autoimmune diseases; 7. The doctor believes that there are other reasons that cannot be included in the treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| saftey;effectiveness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival;MRD;Time to relapse; | — |
Countries
China
Contacts
Public ContactFei Xiaoming
Department of Hematology, Affiliated Hospital of Jiangsu University
Outcome results
None listed