chronic atrophic gastritis
Conditions
Interventions
experimental group:submucosal injection of human umbilical cord-derived mesenchymal stem cells
Control group:submucosal injection of saline
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Volunteer to participate in the trial and sign an informed consent form; 2. Aged 18 to 65 years, regardless of gender; 3. Patients diagnosed as chronic atrophic gastritis (with or without intestinal metaplasia) under endoscopy and pathology; 4. Patients whose C13 breath test is negative or positive in the past have now eradicated Hp; 5. Patients without contraindications to submucosal injection of cord blood stem cells.
Exclusion criteria
Exclusion criteria: 1. Patients suffering from gastric ulcer, erosive gastritis, active upper gastrointestinal bleeding, gastric varices or other gastric tumors; 2. Patients who are taking or have taken proton pump inhibitors, antibiotics, glucocorticoids, non-steroidal anti-inflammatory drugs, immunosuppressants and other drugs in the past six months; 3. Those who have undergone gastric surgery or those who need gastric surgery during the study period; 4. Patients with severe systemic diseases (cardio-cerebrovascular disease, liver disease, blood, kidney, lung or liver disease); 5. Pregnant or lactating female patients; 6. Patients who are unwilling to undergo repeated endoscopic examinations and treatments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histopathological scoring of gastric mucosal; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastric mucosa OLGA & OLGIM rating;Gastrin-17;Pepsinogen II/I; | — |
Countries
China
Contacts
Public ContactXu Hongwei
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed