autism spectrum disorder
Conditions
Interventions
Normal development group:no
Intervention control group:Rehabilitation
Intervention trial group:Rehabilitation
Intervention trial group:Probiotic intervention
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria of ASD in DSM-5; 2.Aged 3 to 6 years; 3.The patient's guardian agreed to participate in the study and signed an informed consent; 4.No gastrointestinal treatment, antibiotics and probiotics were used within 1 month before enrollment bacteria.
Exclusion criteria
Exclusion criteria: Children with other mental diseases, craniocerebral organic diseases, severe liver and kidney diseases, cardiovascular diseases, autoimmune diseases, etc..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal intestinal flora detection;Fecal metabolite detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical development assessment;Cognitive ability assessment;Nervous system development assessment;Gastrointestinal conditions such as dietary conditions and stool conditions;Area and number of eczema and urticaria;Peripheral blood samples detect IL-4, IL-6, IL-17a and IL-10 levels and analyze the number of T helper cells (Th1, Th2, Th17) and regulatory T cells (Treg); | — |
Countries
China
Contacts
Public ContactHan Ying
Peking University First Hospital
Outcome results
None listed