autism spectrum disorder
Conditions
Interventions
Normal development group:Nil
Intervention control group:Rehabilitation training
Intervention trial group:Probiotics combined with rehabilitation training
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of ASD in DSM-5; 2. Aged 3 to 8 years; 3. The child was voluntarily enrolled in the group, and his guardian agreed to participate in the study and signed an informed consent form; 4. Not receive gastrointestinal treatment within 1 month before enrollment, no antibiotics and probiotics are used.
Exclusion criteria
Exclusion criteria: 1. Autism-like manifestations caused by other diseases; 2. Children with other mental diseases, craniocerebral organic diseases, severe liver and kidney diseases, cardiovascular diseases, etc.; 3. History of probiotic allergy in children.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area and number of eczema and urticaria;Peripheral blood samples detect IL-4, IL-6, IL-17a and IL-10 levels and analyze the number of T helper cells (Th1, Th2, Th17) and regulatory T cells (Treg); | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal intestinal flora detection;Fecal metabolite detection;Physical development assessment;Cognitive ability assessment;Nervous system development assessment;Gastrointestinal conditions such as dietary conditions and stool conditions; | — |
Countries
China
Contacts
Public ContactHan Ying
Peking University First Hospital
Outcome results
None listed