Sedative treatment of patients with mechanical ventilation
Conditions
Interventions
remazolam toluenesulfonate group:remazolam toluenesulfonate is sedated in severe patients
midazolam group:midazolam is sedated in severe patients
Sponsors
Liaoning Health Industry Group Fukuang General Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Aged from 30 to 60 years, BMI 18-28kg/m2, regardless of gender; 2.Initial RASS score >= 3, patients with mechanical ventilation by inserting respiratory tube; 3.Sign the informed consent before the activitis related to this study, understand the procedures and methods of this study, and be willing to complete this study.
Exclusion criteria
Exclusion criteria: 1.Allergy to study drugs; 2.Patients who suffer from serious diseases of central nervous system, such as coma; 3.Patients who suffer from dysfunction of important organs, such as heart, liver and kidney.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The patient achieved the dose of the target RASS score;The onset time of the drug;the changes of liver and kidney functions (serum bilirubin and serum creatinine values);the recovery time of the patients after drug withdrawal; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs (such as BP /HR/RR/SpO2%, etc.) and adverse reactions were recorded; | — |
Countries
China
Contacts
Public ContactZhang Yan
Liaoning Health Industry Group Fukuang General Hospital
Outcome results
None listed