Comparison of the effects of sodium bicarbonate Ringer's solution and normal saline on acid-base balance in patients with diabetic ketoacidosis

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046311

Enrollment

Unknown

Registered

2021-05-13

Start date

2021-05-10

Completion date

Unknown

Last updated

2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic ketoacidosis

Interventions

sodium bicarbonate Ringer solution group:Use sodium bicarbonate Ringer solution as the main fluid for fluid therapy for patients with diabetic ketoacidosis

normal saline group:Use normal saline as the main fluid for fluid therapy for patients with diabetic ketoacidosis

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 75 years; 2. Patients with diabetic ketoacidosis: (1) Blood sugar level>13.9mmol/L; (2) Blood ketone >= 3mmol/L or positive urine ketone body (urine ketone body test ++ above); (3) Blood pH (acid-base) < 7.35 and/or HCO3-<21mmol/L); 3. The patient or the legal guardian signs the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients during pregnancy or lactation; 2.Patients with HIV infection and other known immunodeficiencies (use of immunosuppressive drugs, tumors, etc.); 3.Patients with liver and kidney insufficiency in the past medical history; 4.Patients who have participated in other clinical studies 3 months before screening; 5.Other situations deemed unsuitable by the investigator.

Design outcomes

Primary

Measure	Time frame
Base excess;	—

Countries

China

Contacts

Public ContactLuo Zhenchun

Chongqing Traditional Chinese Medicine Hospital

1219600320@qq.com+86 13368380320

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026