Clinical study of vagal nerve stimulation in the treatment of treatment-resistant depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046310

Enrollment

Unknown

Registered

2021-05-13

Start date

2020-03-01

Completion date

Unknown

Last updated

2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

treatment-resistant depression

Interventions

experimental group:vagal nerve stimulation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The results showed that the patients were in accordance with the criteria of classification and diagnosis of mental disorders in China, version 3 (CCMD-3) "severe depression without psychosis symptoms"; 2. Over 18 years old and under 65 years old; 3. Hamilton Depression Scale score of 24 items (hamd-24) was more than 20 points; 4. The efficacy was not good after sufficient foot therapy of antidepressants with two or more different chemical structures.

Exclusion criteria

Exclusion criteria: No history of schizophrenia, schizoaffective disorder, any other psychotic disorder, or a current major depressive episode that included psychotic features; no history of rapid-cycling bipolar disorder; and no previous use of VNS.

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Scale score;brain-derived neurotrophic factor,BDNF;cerebral blood flow;	—

Countries

China

Contacts

Public ContactZhang Xun

The Affiliated Brain Hospital of Guangzhou Medical University

524162780@qq.com+86 18620077993

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026