Severe dry eye disease
Conditions
Interventions
minor salivary gland group 1:minor salivary gland transplantation for terminal severe dry eye caused by Steven-Johnson syndrome
submandibular group:submandibular gland transplantation for terminal severe dry eye caused by Steven-Johnson syndrome.
minor salivary gland group 2:minor salivary gland transplantation for non end stage severe dry eye caused by non Steven-Johnson syndrome
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Obvious, persistent symptoms of dry eye; 2.Eye test: (1)Schirmer test < 2mm; (2)BUT < 5s; (3)Positive fluorescence staining on ophthalmological evaluation or corneal conjunctivalization; (4)Progressive vision loss due to keratoconjunctivitis xerosis; Among the above conditions, ophthalmic evaluation meets (1) and (2), and any one of (3) or (4) is enough.
Exclusion criteria
Exclusion criteria: 1.Multiple major salivary glands are severely damaged; 2.The flow of minor salivary glands in all parts of the body did not meet the minimum flow threshold for minor salivary gland transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective satisfaction score;Subjective dry eye score;Schirmer‘s test;break-up time;fluorescence staining on ophthalmological evaluation;tear meniscus height;best corrected visual acuity; | — |
Countries
China
Contacts
Public ContactSu Jiazeng
Peking University Hospital of Stomatology
Outcome results
None listed