Study on the effect of NMDA receptor antagonist on perioperative pulmonary complications

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046288

Enrollment

Unknown

Registered

2021-05-12

Start date

2021-05-10

Completion date

Unknown

Last updated

2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary complication

Interventions

Experimental group1:Inhale KET

Experimental group2:Inhale saline

Experimental group3:KET i.v.i.v.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged >45 years; 2. ASA anesthesia grade I-III patients; 3. Selective subthoracic pulmonary surgery; 4. No contraindication of paravertebral nerve block; 5. Signing the informed consent for the study.

Exclusion criteria

Exclusion criteria: 1.Body mass index >=30kg/m2; 2.Acute respiratory failure, pneumonia, ALI/ARDS, asthma attack, or mechanical ventilation for more than 1 hour within 3 weeks before surgery within 1 month; 3.Patients who had received oral, nasal, head and neck surgery before surgery; 4.Have a history of allergy to ketamine or similar drugs; 5.Patients with mental diseases, can not cooperate with the atomization operation; 6.Participate in other clinical studies.

Design outcomes

Primary

Measure	Time frame
Pulmonary complication;	—

Countries

China

Contacts

Public ContactHu Jiaqi

Guangdong Provincial People's Hospital

88519598@qq.com+86 13763353320

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026