ischemic stroke
Conditions
Interventions
the 
expression 
of 
CircoGDH 
in 
 
used 
to 
Gold Standard:According to the 2018 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke:
1. Acute onset
2. Defect of meridian function of kitchen god
3. Imaging lesions or symptoms/signs lasting more than 24 hours
4. Exclude non-vascular etiology
5. Brain CT/MRI to exclude bleeding.
Index test:1. 
quantitative 
was 
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Control group: 1. Aged >=18 years; 2. Normal neurological physical examination; 3. patients or their family signed informed consent. Acute cerebral infarction group: 1. Aged >=18 years; 2. Acute cerebral infarction (onset <=24h); 3. Cerebral infarction confirmed by cranial MRI; 4. First stroke, or previous stroke history, but the pre-onset MRS score <=1; 5. Meet the following diagnostic criteria: According to the 2018 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke: (1)Acute onset; (2)Neurological function deficit ; (3)Imaging lesions or symptoms/signs lasting more than 24 hours; (4)Exclude non-vascular etiology; (5)Brain CT/MRI to exclude bleeding. 6. Patients or their family signed informed consent.
Exclusion criteria
Exclusion criteria: Control group: Previous history of stroke, severe cardiopulmonary, hepatic and renal insufficiency, other serious underlying diseases such as myocardial infarction, blood disease, peripheral vascular disease or other thrombotic diseases. Acute cerebral infarction group: 1. Patients with incomplete clinical data, non-stroke death and lost to follow-up; 2. Transvenous thrombolysis and mechanical thrombectomy; 3. Previous history of severe cardiopulmonary, hepatic and renal insufficiency, other serious underlying diseases such as myocardial infarction, blood disease, peripheral vascular disease or other thrombotic diseases; 4. Patients with dementia, Parkinson's disease, tumor, epilepsy, mental illness, etc.; 5. Patients with neurological impairment or loss caused by other non-vascular causes, such as brain trauma, subdural hematoma, brain tumor, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CircOGDH expression level in plasma;Size of ischemic penumbra; | — |
Countries
China
Contacts
Public ContactXu Anding
The First Affiliated Hospital of Jinan University
Outcome results
None listed