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Treatment of dystonia in patients with hepatolenticular degeneration by repetitive transcranial magnetic stimulation (rTMS)

Treatment of dystonia in patients with hepatolenticular degeneration by repetitive transcranial magnetic stimulation (rTMS)

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046258
Enrollment
Unknown
Registered
2021-05-12
Start date
2021-06-01
Completion date
Unknown
Last updated
2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatolenticular degeneration(Wilson's disease)

Interventions

Experimental group:Repeat transcranial electrical stimulation
Control group:sham protocols

Sponsors

The First Affiliated Hospital of Anhui University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1.Comply with WD diagnosis criteria of Western medicine; 2.Conformed to WD brain type; 3.Aged 15 to 35 years; 4.Patients with first diagnosis who had not received copper removal therapy with drugs such as dimercaptopropanesulfonate injection (DMPS) within 2 months before admission; 5.After careful specialist examination by two attending physicians or more, the patient's muscle tension was determined to be increased; 6.Informed consent was signed by the patient or his family.

Exclusion criteria

Exclusion criteria: 1. Patients who do not meet the clinical manifestations of phlegm and blood stasis intercombination; 2. Complicated with other diseases, proved to be unrelated to WD, and confirmed that there may be diseases affecting bone and muscle, such as craniocerebral trauma, infection, high fever, viral hepatitis, etc.; 3. Accompanied by mental disorders; 4. Severe insufficiency of heart, liver and kidney.

Design outcomes

Primary

MeasureTime frame
Muscle biomechanical properties;Spasticity rating scale;Wilson's disease;

Secondary

MeasureTime frame
activities of daily living;

Countries

China

Contacts

Public ContactYang Wenming

The First Affiliated Hospital of Anhui University of Chinese Medicine

nicewj1129@163.com+86 18156078368

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 13, 2026