Critically ill
Conditions
Interventions
Experimenal group:Remimazolam
Control group:propofol
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years, gender is not limited; 2.The estimated mechanical ventilation time is >= 6h; 3.18kg/m^2 <= BMI <= 30kg/m^2; 4.Patients or their family members have a full understanding of this trial, voluntarily participate in this clinical study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Patients with neuromuscular block; 3. Severe central nervous system lesions (including cerebrovascular accident of acute period, uncontrolled seizures, severe slow dementia, depression, schizophrenia, Glasgow coma scale 12 points or less), require blood purification treatment, patients with acute liver disease, acute coronary syndrome, II~III heart block, patients with hemodynamic instability (filter systolic blood pressure or less 90 MMHG or patients on vasoactive drugs); 4. Contraindications clearly specified in the instructions; 5. Other circumstances in which the investigator determines that the patient is not suitable to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of time spent maintaining the target sedation range, number of rescues and cases; | — |
Secondary
| Measure | Time frame |
|---|---|
| The average total amount of fentanyl used for analgesia during medication period and the number of medication cases were studied.Total mechanical ventilation time;Duration of stay in ICU;Endotracheal intubation time;The BIS value; | — |
Countries
China
Contacts
Public ContactLiu Xu; Fu Jianyu
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed