resistant hypertension
Conditions
Interventions
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Sign and date prior to the procedures prescribed in any study; 2. Male and female subjects; 3. Aged >= 18 years; 4. Not involved in other HTN studies; 5. The resistant hypertension group received at least 3 different pharmacological classes of antihypertensive therapy, including diuretics at least 4 weeks prior to screening (1 visit); Systolic blood pressure (SBP) >=140mmHg and/or diastolic blood pressure (DBP) >=90 mmHg in the clinic, or daily mean blood pressure (DBP) >=135/85mmHg in dynamic blood pressure monitoring, 24-hour mean blood pressure (DBP) >=130/80mmHg, and night mean blood pressure (DBP) >=120/70mmHg; The controlled hypertension group consisted of primary hypertension patients whose blood pressure was lower than the target value after standard antihypertensive treatment. The healthy control group recruited healthy volunteers from the physical examination center.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating subjects; 2. Apparent/pseudo RH due to white coat effect, medical inertia, poor treatment compliance, or secondary causes of hypertension (excluding obstructive sleep apnea); 3. Previous cardiovascular diseases: acute myocardial infarction, stroke, heart failure, angina pectoris, peripheral arterial insufficiency; 4. Severe renal insufficiency; 5. Limit study participants to chronic diseases or life expectancy < 18 months (e.g., cancer); 6. Gastrointestinal diseases (including inflammatory bowel disease, celiac disease, lactose intolerance, chronic pancreatitis, or other absorptive diseases); 7. Use antibiotics or probiotics within the last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the metabolites of blood;gut micobiota; | — |
Countries
China
Contacts
Public ContactLi Zhao
The First Hospital of China Medical University
Outcome results
None listed