colorectal cancer
Conditions
Interventions
control group:placebo
Sponsors
The First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients who had been diagnosed with colorectal neoplasms or other conditions requiring elective colorectal surgery (including partial resection and total resection, the surgical procedures were conventional open laparotomy and two or three hole laparoscopic surgeries) without obvious contraindications to surgery; 2.The patients and their families voluntarily participated in this clinical trial and signed the relevant informed consent forms after taking the informed consent talk of the clinical trial.
Exclusion criteria
Exclusion criteria: 1. Patients taking various classes of antibiotic medications on their own or under medical advice for various reasons within 2 weeks before surgery; 2. Those with a previous diagnosis or current diagnosis of inflammatory bowel disease; 3. Those diagnosed with acute intestinal perforation or acute small intestinal diverticulum; 4. Those with ischemic colitis or infectious colitis were included in the diagnosis; 5. Patients requiring two or more procedures simultaneously; 6. Patients who had been diagnosed with acute on chronic peritonitis or other infectious diseases requiring anti infective treatment in the perioperative period; 7. Any acute physiological disturbance indicating that the patient is in need of emergency surgery without elective surgery (e.g.: need for preoperative mechanical ventilation, acute renal failure before surgery, systemic inflammatory release syndrome before surgery, sepsis or septic shock, etc); 8. ASA was rated on a 5-level scale; 9. Patients with immunodeficiency, immunosuppression, or autoimmune disease (e.g., allogeneic bone marrow transplant patients within nearly five years, taking immunosuppressive drugs, SLE, etc.); 10. Other situations in which the patient was unable to cooperate normally with the physician for personal reasons or in which the investigator considered it unsuitable for participation in the experiment; 11. All single port laparoscopic procedures, transhiatal natural orifice procedures, and various new surgical procedures are required. (the above patients met the exclusion criteria all use antibiotics in various ways due to the need for anti infective treatment in the perioperative period, their perioperative laboratory findings and their prognosis will be affected, do not meet the purpose of this experiment, therefore need to be excluded.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative liver metastasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative and postoperative complications;Unplanned secondary surgery;30 - day readmission rates;1-year survival;3-year survival;5-year survival;relapse-free survival;Overall survival; | — |
Countries
China
Contacts
Public ContactJi Gang
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed