Parkinson's disease
Conditions
Interventions
Control Group:placebo
Sponsors
Xinhua Hospital, Affiliated to Shanghai Jiaotong University, School of Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 45 to 80 years with primary Parkinson's disease, regardless of gender; 2.Hoehn-Yahr grading = 24 points; 4.Accompanied with depressive symptoms (8 <= HAMD17 < 18); 5.Stable basic treatment for Parkinson's disease; 6.Sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Other nervous system diseases, mental diseases and serious physical diseases; 2.History of alcohol and drug dependence; 3.Dementia patients; 4.High risk of suicide or suicide attempt within 6 months (HAMD-17 item 3 >= 3 points); 5.Antidepressant treatment or other psychotic treatment in the past month; 7.Those who participated in other clinical trials in recent 3 months; 8.Pregnant or lactating women; 9.Patients considered unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change of Hamilton depression scale during the treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| the change of Hamilton Anxiety Rating Scale during the treatment;the change of clinical global impression scale during the treatment;Pittsburgh Sleep Scale; | — |
Countries
China
Contacts
Public ContactLiu Zhenguo
Xinhua Hospital, Affiliated to Shanghai JiaoTong University, School of Medicine, Shanghai, China
Outcome results
None listed