Periodontal disease and diabetes
Conditions
Interventions
Group A:Supragingival Scaling
Group B:Systematic periodontal therapy
Sponsors
Shanghai Stomatological Hospital
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Over 35 years old (35 inclusive), male or female; 2. 7.0% < HbA1c < 9.0%; 3. Moderate to severe periodontitis (has more than 20 periodontal pockets, the depth of periodontal pocket is more than 4mm, and alveolar bone resorption is more than 30%); 4. Has at least 15 teeth in the mouth; 5. Agree to avoid pregnancy during the study; 6. No periodontal treatment within 6 months; 7. Under the treatment of the physician, there was no change in the medication for diabetes in the last 3 months, and agreed not to change the medication for diabetes when there was no clinical indication during the study period; 8. Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Uncontrolled systemic diseases other than diabetes (cardiovascular disease including hypertension, liver disease, lung disease, end-stage renal failure, or cancer); 2. Hepatitis B or HIV infection; 3. Using chronic therapeutic drugs that affect periodontal tissue (> 2 weeks) (phenytoin sodium or cyclosporine); 4. Chronic systemic antibiotic or immunosuppressive therapy; 5. Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glycosylated hemoglobin (HbA1c); | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor (TNF-a);C-reactive protein (CRP);Fasting plasma glucose (FPG);Creatinine;Insulin;HOMA2;Gingival index (GI);Bleeding on probing (BOP);gingival margin enamel cementum junction (GM-CEJ);Number of missing teeth (TM);Calculus index (CI);Visit depth (PD);Plaque index (PLI); | — |
Countries
China
Contacts
Public ContactWang Yan
Shanghai Stomatological Hospital
Outcome results
None listed