Postoperative wound infection
Conditions
Interventions
Group A:Prophylactic intravenous drip of ertapenem 1.0g in a single-dose intravenous administration 1 hour before the skin incision and within 24 hours after the operation through the levator ani, ext
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Patients with rectal cancer undergoing levator anus external abdominal perineum combined proctectomy (ELAPE); 3. General status ECOG (Eastern Cooperative Oncology Group) determines the clinical status as 0-1 grade; 4. Those who are expected to survive more than 6 months; 5. Liver and kidney functions are normal: such as plasma total bilirubin and creatinine =90g/L; 7. The subject voluntarily joined the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with immunodeficiency; 2. Those who are allergic to carbapenem drugs; 3. Those who are taking antibiotics for other reasons; 4. Creatinine clearance rate < 30ml/min and those with severe kidney disease or requiring dialysis; 5. Combined with other serious diseases: such as myocardial infarction and uncontrollable diabetes within 6 months, which are considered unsuitable to participate in the trial; 6. Pregnant women and patients with mental illness; 7. Participate in other drug clinical trials within 3 months; 8. According to the judgment of the investigator, the subject has other factors that may cause him to be forced to terminate the study halfway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of perineal incision infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perineal incision pain score;Perineal incision infection readmission rate;Postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactHuang Ying
Fujian Medical University Union Hospital
Outcome results
None listed