Effect of Intravenous Injection of Dexamethasone on Stress After Total Hip Arthroplasty

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046173

Enrollment

Unknown

Registered

2021-05-08

Start date

2021-08-01

Completion date

Unknown

Last updated

2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the hip, necrosis of femoral head

Interventions

A:Nil

B:Dexamethasone 10mg before surgery

C:Dexamethasone 20mg before surgery

D:Dexamethasone 20 mg before surgery, 10 mg dexamethasone one day after surgery

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with hip osteoarthritis and femoral head necrosis with indications for unilateral initial artificial Total hip arthroplasty; 2. Aged over 18 years; 3. BMI: 18.5-24kg/?.

Exclusion criteria

Exclusion criteria: 1. History of previous surgery, trauma history, chronic infection of the hip joint on the same side; 2. Combined with diabetes, poorly controlled hypertension, severe heart and lung disease, digestive tract disease, liver and kidney dysfunction, rheumatic immune system disease or mental illness History; 3. Combined with decreased adrenal cortex function; 4. Allergy to dexamethasone; 5. History of alcohol or drug abuse.

Design outcomes

Primary

Measure	Time frame
Fasting blood-glucose;Insulin;C-peptide;Cortisol;Adreno-cortico-tropic-hormone(ACTH);	—

Secondary

Measure	Time frame
Inflammatory markers;Visual Analogu Scale score;Range of motion;Complications;	—

Countries

China

Contacts

Public ContactKang Pengde

West China Hospital of Sichuan University

kangpengde1969@163.com+86 18980601953

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026