Clinical Study of Bright Light Therapy Combined with Transcranial Magnetic Stimulation in the Treatment of Depression

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046171

Enrollment

Unknown

Registered

2021-05-08

Start date

2021-05-15

Completion date

Unknown

Last updated

2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Group A:Light Combined with Transcranial Magnetic Stimulation Sham Stimulation

Group B:Light Combined with Transcranial Magnetic Stimulation True Stimulation (Occipital Lobe)

Group C:Light Combined with Transcranial Magnetic Stimulation True Stimulation (Dorsolateral Prefrontal)

Eligibility

Sex/Gender

All

Age

14 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Meeting the diagnostic criteria for depression through the SCID-IV clinical interview; 2. Aged 14 to 60 years; 3. The Hamilton Depression Scale (HAMD-24) score was above 18 points; 4. Right-handed, Han nationality.

Exclusion criteria

Exclusion criteria: 1. History of substance dependence; 2. Have a mental illness or history that meets SCID axis I diagnostic criteria; 3. History of brain injury, epilepsy or other brain organic disease; 4. Laboratory examination shows liver and kidney function impairment or other serious physical diseases and metabolic disorders; 5. Meeting contraindications of MRI TMS, and MECT; 6. Pregnant women or lactating patients; 7. Previous family history of epilepsy; 8. Combined with retinal dystrophy, age-related macular degeneration, porphyria, chronic actinic dermatitis, solar urticaria and other diseases; 9. Do not cooperate with treatment plan or cannot be effectively completed; 10. Prior TMS treatment history.

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Scale;Hamilton Anxiety Scale;Scale for Suicide Ideation;Hypomania Check List;Positive and Negative Syndrome Scale;Mood Disorder Questionnaire;GAD-7 Anxiety Screening Scale;Pittsburgh Sleep Quality Index;Life Event Scale;Childhood Trauma Scale;	—

Secondary

Measure	Time frame
Clinical Global Impression;Personal and Social Performance Scale;Treatment Emergent Symptom Scale;TrailMakingTest;Symbolic Coding;RBANS Figure copy;Raven's Standard Progressive Matrices;Autobiographical Memory Test;Hopkins Vocabulary Test;	—

Countries

China

Contacts

Public ContactDeng Wei

West China Hospital of Sichuan University

mrdengwei@163.com+86 18980605805

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026