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Evaluation of Transbronchial Lung Cryobiopsy Freezing Time, Biopsy Size, Histological Quality and Incidence of Complication: a Prospective Clinical Trial

Evaluation of Transbronchial Lung Cryobiopsy Freezing Time, Biopsy Size, Histological Quality and Incidence of Complication: a Prospective Clinical Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100046159
Enrollment
Unknown
Registered
2021-05-07
Start date
2016-04-01
Completion date
Unknown
Last updated
2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tracheobronchial tuberculosis

Interventions

Case series:Within the range of TBCB standard operation procedure, the freezing time increased from 3 to 6 seconds

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The patient aged 18 years old or older, can understand the research procedure and sign the informed consent in writing; 2. The patient is clinically suspected DPLD diagnosis and present symptoms of cough, shortness of breath, dyspnea, with or without fever; 3. The imaging findings highly indicate DPLD: unilateral or bilateral lung fields show nodular, small patchy infiltration, line, grid, honeycomb, miliary, or ground glass shadow; 4. After the laboratory examination, radiology examination, and routine bronchoscopy, a definite diagnosis still cannot be made on MDT discussion.

Exclusion criteria

Exclusion criteria: 1. The patient has severe cardiovascular disease or poorly controlled hypertension; 2. The patient has refractory severe respiratory failure; 3. The patient has bleeding and coagulation dysfunction, resulting in hemostasis difficulty; 4. Preoperative radiology examination indicates that the lung lesions are adjacent to the middle or large vessels, and there is a great risk of bleeding; 5. The patient cannot intolerant or has difficulty in cooperating with bronchoscopy exam; 6. The routine bronchoscopy exam shows abnormalities that make biopsy impossible; 7. Pregnancy; 8. Other conditions that may increase the risk of surgery.

Design outcomes

Primary

MeasureTime frame
Biopsy size;

Secondary

MeasureTime frame
Safety;

Countries

China

Contacts

Public ContactShuliang Guo

The First Affiliated Hospital of Chongqing Medical University

guosl999@sina.com+86 13101363078

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026