Type 2 Diabetes Mellitus
Conditions
Interventions
Exercise group:Combined aerobic and resistance exercises
Control group:Maintain their usual lifestyle unchanged
Sponsors
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with type 2 diabetes mellitus; 2. Not more than three anti-diabetic medications 3. The anti-diabetic medications are stable for at least 6 weeks, and remain unchanged during exercise intervention; 4. Aged from 35 to 65 years; 5. Abdominal obesity: waist circumference >= 90cm for males and >= 80cm for females; 6. Body mass index (BMI) = 1.7, female >= 1.6; 8. Sedentary lifestyle (<= 60 minutes of moderate-intensity activities per week).
Exclusion criteria
Exclusion criteria: 1. HbA1c = 9%; 2. Insulin usage; 3. Presence of one or more of the following complications: severe proliferative diabetic retinopathy or worse, macroalbuminuria (urine albumin-creatinine ratio >= 300mg/g), or renal dysfunction (eGFR <= 60ml/min/1.73 m2); 4. History of cardiovascular events, including myocardial infarction, percutaneous coronary intervention (PCI), unstable angina, heart failure, and cardiac insufficiency; 5. History of cerebrovascular diseases, including hemorrhagic and ischemic stroke; 6. Muscle, bone, or neuromuscular injuries that will prevent training exercises; 7. Severe osteoporosis, or suboptimal bone density test results even after treatment; 8. Pregnancy; 9. Not able or unwilling to undergo magnetic Resonance Imaging (MRI), including claustrophobia, implantable cardioverter defibrillator and pacemaker; 10. Diagnosed depression or any mental illness rendering the patients unable to understand the nature, scope and possible sequences of the study; 11. Patients who take drugs that are unstable or affect glucose metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in body fat mass; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in insulin sensitivity;Change in HbA1c;Change in body fat percentage;Change in lean mass;Change in lean mass percentage;Change in adipose tissue area;Change in muscle area;Change in appetite;Change in emotion;Change in cognitive function;Change in metagenomics;Change in metabolomics;Change in anthropometry;Change in clinical biochemical indexes;Change in energy metabolism;Change in exercise-related indicators;Change in the levels of cytokines;Change in intrahepatic triglyceride content;Change in muscle oxygen;Change in immunologic function;Percent change in body fat mass;Change in vascular endothelial function;Change in cardiac autonomic neuropathy;Glucose fluctuation;Change in cardiopulmonary fitness; | — |
Countries
China
Contacts
Public ContactJia Weiping
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Outcome results
None listed