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Combining multimodal magnetic resonance imaging and machine learning technology to explore the central mechanism of chronic primary frozen shoulder pain and the central analgesic mechanism of duloxetine

Combining multimodal magnetic resonance imaging and machine learning technology to explore the central mechanism of chronic primary frozen shoulder pain and the central analgesic mechanism of duloxetine

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046144
Enrollment
Unknown
Registered
2021-05-05
Start date
2021-06-30
Completion date
Unknown
Last updated
2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frozen shoulder

Interventions

Sponsors

Tianjin Medical University General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.In patients with frozen shoulder diagnosed by the General Hospital of Tianjin Medical University; 2.Aged from 25 to 65 years; 3.An insidious onset of pain and stiffness with a clinical reduction in range of motion, principally>50% reduction in external rotation; 4.No underlying radiologic abnormality.

Exclusion criteria

Exclusion criteria: 1.A history of shoulder surgery or trauma; 2.Other comorbid shoulder pathology, such as instability, glenohumeral arthritis, rotator cuff tears, calcific tendinopathy, acromioclavicular arthritis or shoulder instability; 3.A history of any psychiatric disorders; 4.Local corticosteroid injection or any physiotherapy intervention to the affected shoulder within the last 1 months; 5.Cerebrovascular accident affecting the shoulder; 6.Concomitant disorders, such as serious infection or systemic disease (rheumatologic, cardiac, respiratory, gastrointestinal, neurological, endocrine, etc.); 7.Histories of neurological diseases or dementia, psychiatric disorders, or inabilities to complete the testing procedures and MRI scans; 8.An unwillingness to participate in the study and patients with drug contraindications.

Design outcomes

Primary

MeasureTime frame
Functional brain imaging;

Secondary

MeasureTime frame
Visual analogue scale;

Countries

China

Contacts

Public ContactXue Yuan

Tianjin Medical University General Hospital

xueyuanzyy@163.com+86 13512003188

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026