Bronchiectasis
Conditions
Interventions
Control group:Muscle stretching of the thorax
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 75 years and clinical diagnosis of bronchiectasis; 2. Patients with bronchiectasis were in stable stage (there was no significant change in respiratory symptoms during the day and night for 4 consecutive weeks, and no acute exacerbation of bronchiectasis or acute upper respiratory tract infection occurred within 4 weeks); 3. More than one pulmonary exacerbation of bronchiectasis occurred in two years; 4. Daily sputum volume in the previous year was >= 10 ml; 5. Patients had not received airway clearance or rehabilitation treatment in the past; 6. Patients are able to receive treatment follow-up and have a certain reading ability.
Exclusion criteria
Exclusion criteria: 1. Cystic fibrosis; 2. Currently smoking or smoking index >= 10 pack-years or HRCT showing emphysema; 3. Previous diagnosis of asthma; 4. Active pulmonary tuberculosis; 5. Any contraindications for airway clearance: pneumothorax, intracranial hypertension, recent history of eye surgery, hemoptysis; 6. Participation in other clinical trials within 3 months before screening; 7. Withdrawal of the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sputum volume during the first intervention and 24 hours later;Quality of Life-Bronchiectasis Respiratory Symptoms scores (QOL-B-RSS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sputum volume during the last intervention and 24 hours later;Number of exacerbations ;Time to exacerbation;Lung function;mMRC scale;6-min walk test;Leicester Cough Questionnaire (LCQ);Bronchiectasis Health Questionnaire (BHQ) score;Hospital Anxiety and Depression Scale (HADS) score;Sputum color and microbiology evaluation;Systemic inflammation biomarkers;Treatment adherence; | — |
Countries
China
Contacts
Public ContactLuo Hong
The Second Xiangya Hospital of Central South University
Outcome results
None listed