Nonalcoholic fatty liver disease
Conditions
Interventions
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patient who meet the diagnostic spleen deficiency and blood stasis syndrome of non-alcoholic fatty liver; 2.Aged 18 to 65 years; 3.MRI-pdff liver fat content > 5%, BMI < 35 kg/m2; 4.Voluntarily follow scheduled medical visits, dietary and exercise instructions, laboratory tests, and other study procedures; 5.ALT less than or equal to 5 times upper than normal limit; 6.Sign patient informed consent.
Exclusion criteria
Exclusion criteria: 1.Someone who have used liver protection drugs and enzyme lowering drugs which can impact on efficacy evaluation in the past 1 month; 2.Someone who have used Tamoxifen, Amiodarone, sodium valproate, methotrexate, glucocorticoids or other drugs which can affects lipid metabolism in the past 3 month; 3.Someone who has comorbidity just like total parenteral nutrition, inflammatory bowel disease, celiac disease, hypothyroidism, Cushing's syndrome, ß-lipoprotein deficiency, lipid atrophic diabetes, Mauriac syndrome and other disease can lead to fatty liver disease; 4.Someone who has alcoholic fatty liver disease (male alcohol intake>30g/d, female alcohol intake>20g/d), cirrhosis, Hepatitis B, Hepatitis C and other liver diseases, autoimmune liver disease or liver decompensating; 5.T2DM patients whose disease without well control (HbA1c >= 9.5% in the past month); 6.ASCVD in high and very high-risk patients; 7.Someone whose weight lose 10% in the past 3 months because of bariatric surgery or diet pills; 8.Someone who with history of substance abuse or drug addiction; 9.Pregnant and lactating women, patients with cardiovascular, lung, kidney, hematopoietic system and other major primary diseases as well as malignant tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI-pdff; | — |
Secondary
| Measure | Time frame |
|---|---|
| weight, body mass index, waist circumference;Serum liver function;Blood fat;Fasting blood glucose, fasting insulin, insulin resistance index;Sf-36 Health Survey Scale score, non-alcoholic fatty liver disease questionnaire;TCM syndrome scale integral; | — |
Countries
China
Contacts
Public ContactZhao Yu
Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine
Outcome results
None listed