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Effect of Intravenous or Perineural Dexmedetomidine and Dexamethasone for Quadratus Lumborum Block on the Quality of Recovery Following Laparoscopic Radical Colorectal Cancer Surgery

Effect of Intravenous or Perineural Dexmedetomidine and Dexamethasone for Quadratus Lumborum Block on the Quality of Recovery Following Laparoscopic Radical Colorectal Cancer Surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046110
Enrollment
Unknown
Registered
2021-05-04
Start date
2021-05-10
Completion date
Unknown
Last updated
2021-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

Dexmedetomidine and dexamethasone intravenous injection group:Intravenous injection
Perineural dexmedetomidine and dexamethasone for QLB group:Compound local anesthesia to block quadratus lumborum muscle

Sponsors

Zhongshan Hospital Affiliated to Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Patients should be given elected laparoscopic radical colorectal cancer surgery under general anesthesia combined with QLB(except for laparoscopic Miles surgery), with no limitation of gender; 2.Aged 18 to 70 years; 3.ASA class I-II ; 4.BMI 18.5-28 kg/m^2; 5.Sign informed consent.

Exclusion criteria

Exclusion criteria: 1.Diabetes mellitus; 2.Contraindications to peripheral nerve block: including local skin infection, bleeding diathesis and coagulopathy; 3.Allergy to the studied drugs (e.g., ropivacaine, dexmedetomidine, dexamethasone, etc.); 4.Baseline heart rate < 60 bpm, baseline systolic blood pressure < 100 mmHg or combined with severe cardiopulmonary dysfunction or hepatic or renal insufficiency; 5.History of combined psychiatric disorders or language communication disorders that prevent cooperation in completing follow-up; 6.History of chronic pain, long-term oral painkillers, alcohol abuse; 7.History of previous colorectal cancer surgery; 8.History of chemotherapy or radiotherapy in the last 8 weeks before surgery; 9.Pregnancy or lactation.

Design outcomes

Primary

MeasureTime frame
Quality of recovery;—

Secondary

MeasureTime frame
Intraoperative and postoperative opioid consumption;The time to first press the analgesic pump after the operation;Pain intensity at the surgical site;Complications of QLB;Laboratory examinations;Length of stay;Chronic postsurgical pain;Incidence of postoperative nausea and vomiting, pruritus, respiratory depression, and dizziness;Time to first defecation/bowel movement, time to eat, time to ambulation;Quality of recovery;—

Countries

China

Contacts

Public ContactGe Shengjin

Zhongshan Hospital Affiliated to Fudan University

shengjinge@163.com+86 13601926171

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026